Searchable abstracts of presentations at key conferences in endocrinology

ea0029p411 | Clinical case reports - Thyroid/Others | ICEECE2012

Double jeopardy in pregnancy: a case of autoimmune polyglandular syndrome type 2 in a pregnant patient

Li R. , Mejia A. , Manalo M. , Lantion-Ang F. , Tamban C.

This is a case of an adult female who presented with 1 year history of palpitations, heat intolerance, easy fatigability, hyperdefecation and proptosis. She was admitted to this institution due to 3 month history of nausea, vomiting, abdominal pain, flank pain and generalized weakness. During admission, she was diagnosed with hyperthyroidism supported by laboratory findings of suppressed thyroid stimulating hormone and elevated free thyroxine levels and was then treated with m...

ea0004p34 | Cytokines and growth factors | SFE2002

IGFBP-3 mRNA expression is reduced in normal colonic mucosa of colorectal patients with colorectal cancer compared to mucosa from non cancer patients

Ogunkolade B , Kelly|P## , S##Khalaf P , Fairclough P , Li R , Ahmed S , Hands R , Bustin S , Jenkins P

Background:Circulating levels of IGFBP-3 are inversely associated with the risk of developing colorectal cancers (CRC). In addition to modulating IGF bioavailability, IGFBP-3 also exerts independent pro-apoptotic effects. Furthermore, the mode of action of several apoptotic and antiproliferative agents, including vitamin D, has been shown to involve induction of IGFBP-3.Aims:To quantitate and compare IGFBP-3 ...

ea0029p338 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Psoriasis is associated with decreased adiponectin levels beyond cardiovascular and metabolic risk factors

Li R. , Krishnamoorthy P. , Yu Y. , Raper A. , Baer A. , Derohannessian S. , Wilcox M. , Vorohees A. , Reilly M. , Rader D. , Gelfand J. , Mehta N.

Introduction: Psoriasis is a systemic inflammatory skin disease, which is associated with increased cardiovascular disease (CVD) potentially through metabolic derangements due to chronic inflammation. Serum adiponectin appears to decrease the risk of CVD and has been shown to negatively associate with waist size and insulin resistance (IR), both of which are increased in psoriasis. It is unknown, however, if psoriasis is associated with decreased adiponectin levels beyond trad...